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ISSN : 2287-7991(Print)
ISSN : 2287-8009(Online)
Journal of the Preventive Veterinary Medicine Vol.45 No.3 pp.144-149

Anti-hyperlipidemic effects of Dendropanax morbifera L. leaf water extract in hyperlipidemic rats fed a high-fat diet

Ye-Jin Kang1, Min-Jae Kim1, Jin-Hyeok Kim2, Yongjae Han2, Kwang-Il Park3, Suk Kim3, Hu-Jang Lee1,3†
1Department of Environmental Health, Graduate School of Public Health, Gyeongsang National University, Chinju 52727, Republic of Korea
2Department of Anesthesiology and Pain Medicine, College of Medicine, Inje University, Busan 47392, Republic of Korea
3Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Chinju 52828, Republic of Korea


The present study is designed to investigate the hypolipidemic effect of the hot-water extract from the leaves of Dendropanax morbifera L. (DMWE) in hyperlipidemic rats. Thirty male 5-week-old rats were grouped as follows: Normal control (NC) given distilled water; hyperlipidemic control (HC) administered with distilled water; drug treatment (DT) orally administered with atorvastatin (10 mg/kg body weight (BW)); DMWE-treated groups (DM-50, DM-100 and DM-200) treated with DMWE 50, 100 and 200 mg/kg BW, respectively. All groups (except for NC) were fed a high-fat diet during the experiment. After 4 weeks of administration, the BW of all groups treated with DMWEs significantly increased compared to that of HC (p<0.05) and showed no significant difference compared to that of NC. In addition, serum total cholesterol levels in all groups treated with DMWEs were meaningfully decreased, compared to that in HC (p<0.05). In serum triglyceride (TG) and low-density lipoprotein-cholesterol levels, both DM-100 and DM-200 considerably decreased compared to HC (p<0.05), and no significant differences in TG levels were between DM-100 and DM-200. In high-density lipoprotein-cholesterol levels, DM-200 was statistically different compared to HC, and there were no significant differences between DM-100, DM-200 and DT. Furthermore, aspartate transaminase and alanine aminotransferase concentrations of DM-100 and DM-200 were significantly decreased compared to those of HC (p<0.05). From results portrayed above, DMWE at the concentration of 100 mg/kg BW has been identified to be effective in the treatment of hyperlipidemic rats.