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ISSN : 2287-7991(Print)
ISSN : 2287-8009(Online)
Journal of the Preventive Veterinary Medicine Vol.44 No.2 pp.45-52
DOI : https://doi.org/10.13041/jpvm.2020.44.2.45

Protective effects of Achyranthes Radix root extract against CDDP-induced liver and kidney damage in SD rats: Application of big data analysis to traditional medicine

Hyeonsoo Park1,Kwang-Youn Kim2,Byung Wook Lee3,4,Young Woo Kim5,Gon Sup Kim6,Chang Keun Kang7,8,Kwnag Il Park7,8†
1Research Center of Stickus corporation, Busan, Republic of Korea
2Korea Medicine (KM)-Application Center, Korea Institute of Oriental Medicine, 70 Cheomdan-ro, Dong-gu, Daegu, 41062, Republic of Korea
3Department of Classics and Medical History, College of Korean Medicine, Dongguk University, Gyeongju, 38066, Republic of Korea
4Dongje Medical Co., Ltd., Republic of Korea
5School of Korean Medicine, Dongguk University, Gyeongju, 38066, Republic of Korea
6Research Institute of Life Science, College of Veterinary Medicine, Gyeongsang National University, Jinju, Gyeongsang 52828, Republic of Korea
7College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea
8Institutes of Animal Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea
Corresponding Author. Kwang Il Park, Tel: +82-55-772-2342, Fax: +82-55-772-2349, E-mail: kipark@gnu.ac.kr

Abstract

Big data analysis methods are useful tools for sorting valuable data and products. Achyranthes Radix root extract (AR) is a well-known herbal medicine in East Asia due to its anti-osteoarthritis, pro-circulatory, and anti-osteoporosis effects. In this stud y, we investigated the liver- and kidney-protective effects of AR by applying big data analysis to traditional medicine. CDDP (cis-diamminedichloridoplatinum) is an effective cancer cell anti-proliferative agent used in the treatment of diverse types of tumors. However, it is clinically limited due to liver and kidney toxicity. The current study was designed to assess the potential protective effects of AR against CDDP-induced hepato-renal toxicity. For this purpose, male Sprague-Dawley (SD) rats were assigned to four groups, each consisting of four animals. Intravenous injection or oral administration of either saline or AR was performed daily for 14 days, whereas CDDP was injected intraperitoneally on day 3 following AR treatment. Serum biochemistry results revealed that CDDP induced clear hepatic and renal damage while the AR treatment groups showed less damage relative to controls. Next, we tested the pharmacokinetics of AR using 20-hydroxyecdysone (20-HE), which is the most abundant component of AR extract. After intravenous administration of AR, the plasma concentration of 20-HE rapidly declined with a terminal half-life (t1/2) of 0.99±0.47 h. The area under the plasma concentration vs. time curve was 24.96±3.5 h*ng/mL. The present study provides valuable tools for further verification studies of the classical herbal literature and its scientific relevance.

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