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ISSN : 2287-7991(Print)
ISSN : 2287-8009(Online)
Journal of the Preventive Veterinary Medicine Vol.43 No.4 pp.201-206

Synergistic antibacterial effects of the combination of sulfamethazine and tiamulin against Salmonella Typhymurium and Actinobacillus pleuropneumoniae isolated from pigs

Won-Suk Chae1,Eun-Kee Park2,Chang-Yeul Yoo3,Suk Kim4,Hu-Jang Lee4†
1Schools of Life-Chemistry, Daejin University, Pocheon 11159, Republic of Korea
2Department of Medical Humanities and Social Medicine, College of Medicine, Kosin University, Busan 49267, Republic of Korea
3Department of Computer Software Science, Gyeongnam Provincial Namhae College, Namhae 52422, Republic of Korea
4Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea
Corresponding Author. Hu-Jang Lee, Tel: +82-55-772-2352, Fax: +82-55-772-2308, E-mail:


This study was investigated the synergistic antibacterial effects from the combination of sulfamethazine (SMZ) and tiamulin (SMT) against Salmonella Typhimurium (S. Typhimurium) and Actinobacillus pleuropneumoniae (A. pleuropneumoniae) isolated from pigs. Minimum inhibitory concentrations (MICs) and fractional inhibitory concentration (FIC) index were determined for 10 bacteria from 13 swine farms in Gyeongsangnam province by the National Committee for Clinical Laboratory Standards broth microdilution procedure. Antimicrobial agents tested included SMZ, tiamulin and SMT. Against S. Typhimurium and A. pleuropneumoniae, the MIC ranges of SMZ, tiamulin and SMT were 125-500, 15.625-62.5 and 15.625-62.5 μg/mL, respectively. In addition, the FIC index ranges of SMT against S. Typhimurium and A. pleuropneumoniae were 0.19-0.38 and 0.19-0.62, respectively. In conclusion, SMT has a high antibacterial activity against S. Typhimurium and A. pleuropneumoniae, then the combination may be applied for the treatment of swine diseases caused by S. Typhimurium and A. pleuropneumoniae.