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ISSN : 2287-7991(Print)
ISSN : 2287-8009(Online)
Journal of the Preventive Veterinary Medicine Vol.43 No.2 pp.53-57

Acute oral toxicity test of Chamaecyparis obtuse essential oil on New Zealand white rabbits

Chun-Nam Cha1,Eun-Kee Park2,Chang-Yeul Yoo3,Suk Kim4,Hu-Jang Lee4†
1Engineering Research Institute, Department of Industrial Systems Engineering, Gyeongsang National University, Chinju 52828, Republic
of Korea
2Department of Medical Humanities and Social Medicine, College of Medicine, Kosin University, Busan 49267, Republic of Korea
3Department of Smart Information Convergence, Gyeongnam Provincial Namhae College, Namhae 52422, Republic of Korea
4Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Chinju 52828, Republic of Korea
Corresponding Author. Hu-Jang Lee, Tel: +82-55-772-2352, Fax: +82-55-772-2308,


This study was carried out to investigate the acute oral toxicity of Chamaecyparis obtusa (C. obtusa) essential oil (CBE) in New Zealand white male and female rabbits. Acute oral treatment with the CBE did not reveal any sign of toxicity or mortality in treated rabbits. The body weight of the rabbits was not affected after a single oral administration of the CBE during the 14-day observation period. In both the hematological and blood biochemical analysis, all parameters of the treated group with 2,000 mg/kg body weight of the CBE were not significantly different than those of the control group. Therefore, the lethal dose 50 of the CBE was estimated to be greater than 2,000 mg/kg body weight in rabbits, which indicated that the CBE is non-toxic. In conclusion, this study suggests that oral administration of the CBE is safe on rabbits.