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ISSN : 2287-7991(Print)
ISSN : 2287-8009(Online)
Journal of the Preventive Veterinary Medicine Vol.42 No.4 pp.182-185
DOI : https://doi.org/10.13041/jpvm.2018.42.4.182

Toxicity of a combination of florfrenicol and acetaminophen in pigs administered at overdose

Won-Seok Chae1,Chang-Yeul Yoo2,Lütfiye Tutkun3,Suk Kim4,Hu-Jang Lee4†
1Schools of Life-Chemistry, Daejin University, Pocheon 11159, Republic of Korea
2Department of Computer Software Science, Gyeongnam Provincial Namhae College, Namhae 52422, Republic of Korea
3Department of Medical Biochemistry, Bozok University, Yozgat 66900, Turkey
4Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Chinju 52828, Republic of Korea
Corresponding Author. Hu-Jang Lee, Tel: +82-55-772-2352, Fax: +82-55-772-2308,
E-mail: hujang@gnu.ac.kr

Abstract

This study examined the overdose toxicity of Super-Neophensan, containing florfenicol and acetaminophen, upon pigs. SNP-3.0 (n=10) was administered at the dosage level of 3 kg/ton feed for 7 consecutive days, which is 3 times the recommended dose based on the guidelines of the manufacturer, and the control group (CON) (n=10) was administered the normal diet without the drug. The body weight, weight gain and feed efficiency in SNP-3.0 treated with the drug for 14 days post-administration showed no significant differences compared with those in CON. In hematological and blood biochemical analyses, all parameters were not affected by over-dosage of the drug. In the same way, there were no significant differences between SNP-3.0 and CON on markers for liver and kidney functions. As no adverse effects were observed with the drug in an overdose oral toxicity test, this study suggests that the drug was identified as a safe agent in pigs administered with three times the recommended dose.

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