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ISSN : 2287-7991(Print)
ISSN : 2287-8009(Online)
Journal of the Preventive Veterinary Medicine Vol.42 No.3 pp.124-132

Acid resistance mechanisms in enterohemorrhagic Escherichia coli O157:H7

Seon Mi Wi,Jang Won Yoon
College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 24341, Republic of Korea
Corresponding Author. Jang Won Yoon, Tel: +82-33-250-8791, Fax: +82-33-259-5625


Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a food-borne bacterial pathogen that causes various diseases in both humans and animals such as hemorrhagic colitis and hemolytic uremic syndrome. Because cattle are the main reservoir of this microorganism, undercooked meat and meat byproducts contaminated with EHEC O157:H7 are most commonly associated with epidemic disease outbreaks. As an enteric pathogen, EHEC O157:H7 enters the body via a fecal-oral route and must survive passage through the gastric stomach at pH 1.5 to 3.5 to establish an infection within the gastrointestinal tracts. Therefore, the ability to resist such acidic environments is important to the pathogenesis of EHEC O157:H7 during a host infection. In this review, we will discuss on the acid resistance (AR) mechanisms induced by EHEC O157:H7 when E. coli encounters acidic environments.