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ISSN : 2287-7991(Print)
ISSN : 2287-8009(Online)
Journal of the Preventive Veterinary Medicine Vol.41 No.4 pp.193-196
DOI : https://doi.org/10.13041/jpvm.2017.41.4.193

Single-dose acute toxicity of orally administered
Super-Neophensan containing florfenicol and
acetaminophen in Sprague-Dawley rats

Won-Seok Chae1, Chun-Nam Cha2, Chang-Yeul Yoo3, Suk Kim4, Hu-Jang Lee4†
1Schools of Life-Chemistry, Daejin University
2Engineering Research Institute, Department of Industrial Systems Engineering, Gyeongsang National University
3Department of Smart Information Convergence, Gyeongnam Provincial Namhae College
4Research Institute of Live Sciences, College of Veterinary Medicine, Gyeongsang National University

Abstract

This study examined the acute toxicity of Super-Neophensan containing florfenicol and acetaminophen in male and female Sprague-Dawley rats. Rats were orally administered the drug at dose levels of 0, 250, 500, 1,000 and 2,000 mg/kg body weight (BW) for the single-dose toxicity test. BW changes in all treated groups were not significantly different to those in the control treated with saline. In hematological and blood biochemical analyses, all parameters were unaffected by the drug. In the same way, there were no significant differences between all treated groups and the control group in terms of markers for liver and kidney functions. As no adverse effects were observed with the drug in the single-dose oral toxicity test, even at the highest concentration of the drug, the lethal dose 50 (LD50) of Super-Neophensan is estimated to be greater than 2,000 mg/kg BW.

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